Table 1.
Viability of ovarian cancer cells treated with mibefradil or carboplatin.
| Cell line | Mibefradil EC50 ± SEM (μmol/L) |
Carboplatin EC50 ± SEM (μg/mL) |
|---|---|---|
| A2780 | 6.6 ± 0.7 | 5.9 ± 0.83 |
| A2780Cis | 7.7 ± 0.8 | 19 ± 2.3 |
| IGROV-1 | 9.6 ± 0.8 | 14 ± 2.1 |
| SKOV3.ip1 | 13 ± 2.2 | 18 ± 3.3 |
Cells were treated with mibefradil continuously for 72 hours, and viability was determined by Alamar Blue assay as described (see Material and Methods). Values represent the average of ≥ three independent experiments ± SEM. EC50 – drug concentration that decreased viability 50%.