Table 2.

Impact of low vs. high maternal LG on neuroendocrine outcomes in adult female Long-Evans rats

Brain Region	Effect of low vs. high LG	Reference
lateral septum	↓ oxytocin receptor binding	Champagne et al. (2007)
	↓ estrogen-induced oxytocin receptor binding	Champagne et al. (2001)
BNST	↓ oxytocin receptor binding	Francis et al. (2002)
MPOA	↓ oxytocin receptor binding	Champagne et al. (2007)
	↓ estrogen-induced oxytocin receptor binding	Champagne et al. (2001)
	↓ ERα mRNA and protein; ↓ estrogen-induced cFos	Champagne et al. (2003)
	↑ Esr1 promoter DNA methylation ↓ Stat5b binding to the Esr1 promoter	Champagne et al. (2006)
	↓ OTR mRNA; ↓ ERα-IR; ↑ Esr1 promoter DNA methylation; ↓ H3K4me3 at Esr1 promoter	Pẽna et al. (2013)
	↑ estrogen-induced GnRH-IR	Cameron et al. (2008)
anteroventral paraventricular nucleus of the hypothalamus	↑ ERα mRNA; ↑ estrogen-induced pERα	Cameron et al. (2008)
ventromedial hypothalamus (VMH)	↑ pERα-IR (proestrus); ↓c-Fos-IR (proestrus)	Cameron et al. (2011)
	↑ Stat5b binding to the Esr1 promoter	Cameron et al. (2008)
hippocampus	↓ EPSPs	van Hasselt et al. (2012)
PVN	↓ oxytocin receptor binding	Champagne et al. (2007)
amygdala (CN)	↓ oxytocin receptor binding	Francis et al. (2002)
VTA	↓ TH-IR ↓ Lmx1b mRNA; ↓ BDNF mRNA	Pẽna et al. (2014)