Table 3.
Brain region | Sex | Age | Effect of low vs. high LG | Reference |
---|---|---|---|---|
PFC | male | PND 40 | ↑5-HT turnover (ratio of 5H1AA/5-HT) | Masís-Calvo et al. (2013) |
nucleus accumbens | female | PND 21 | ↓ DRD1, ↓ DRD2, ↓ DRD3 mRNA | Pẽna et al. (2014) |
male | PND 40 | ↓5-HT turnover, ↓ TrkB mRNA | Sequeira-Cordero et al. (2013) | |
ventral striatum | male | PND 40 | ↑ DOPAC | Masís-Calvo et al. (2013) |
MPOA | female | PND 6 | ↓ ERα mRNA; ↓ Stat5b protein |
Champagne et al. (2006) |
↓ ERα-IR | Pẽna et al. (2013) | |||
female | PND 21 | ↓ ERα, ↓ ERβ mRNA; ↑ Esr1 promoter DNA methylation; ↓ H3K4me3 at Esr1 promoter; ↑ H3K9me3 at Esr1 promoter |
Pẽna et al. (2013) | |
female | PND 40 | ↓ ERα-IR | Pẽna et al. (2014) | |
hippocampus | male | PND 4 | ↓ GAD1 mRNA | Zhang et al. (2010) |
↓ NGFI-A, CBP, NAB1, NAB2 and Sp1 protein | Hellstrom et al. (2012) | |||
male | PND 6 | ↑ Nr3c1 DNA methylation | Weaver et al. (2004) | |
↓ GR mRNA and protein; ↓CBP, H3K9Ac and NGFI-A binding to the Nr3c1 promoter |
Weaver et al. (2007) | |||
↓ MBD2 mRNA | Weaver et al. (2014) | |||
male | PND 8 | ↓ BDNF mRNA; ↓ NR2A, ↓ NR2B NMDAR subunit mRNA |
Liu et al. (2000) | |
male | PND 21 | ↓ neuronal survival; ↑ apoptosis; ↓ bFGF |
Bredy et al. (2003) | |
↑ Nr3c1 DNA methylation | Weaver et al (2004) | |||
↓ BDNF mRNA (exon IX) | van Hasselt et al. (2012) | |||
male | PND 18 | ↓ synaptophysin, ↓NCAM protein; ↓ NR2A, ↓ NR2B NMDAR subunit mRNA | Liu et al. (2000) | |
male | PND 40 | ↓5-HT turnover | Sequeira-Cordero et al. (2013) | |
VTA | female | PND 6 | ↓ TH-IR ↓ cdkn1c mRNA |
Pẽna et al. (2014) |
female | PND 21 | ↓ Lmx1b mRNA | Pẽna et al. (2014) | |
female | PND 40 | ↓ TH-IR | Pẽna et al. (2014) |