Table 3.

Developmental impact of low vs. high maternal LG on neuroendocrine outcomes in Long-Evans rats

Brain region	Sex	Age	Effect of low vs. high LG	Reference
PFC	male	PND 40	↑5-HT turnover (ratio of 5H1AA/5-HT)	Masís-Calvo et al. (2013)
nucleus accumbens	female	PND 21	↓ DRD1, ↓ DRD2, ↓ DRD3 mRNA	Pẽna et al. (2014)
	male	PND 40	↓5-HT turnover, ↓ TrkB mRNA	Sequeira-Cordero et al. (2013)
ventral striatum	male	PND 40	↑ DOPAC	Masís-Calvo et al. (2013)
MPOA	female	PND 6	↓ ERα mRNA; ↓ Stat5b protein	Champagne et al. (2006)
			↓ ERα-IR	Pẽna et al. (2013)
	female	PND 21	↓ ERα, ↓ ERβ mRNA; ↑ Esr1 promoter DNA methylation; ↓ H3K4me3 at Esr1 promoter; ↑ H3K9me3 at Esr1 promoter	Pẽna et al. (2013)
	female	PND 40	↓ ERα-IR	Pẽna et al. (2014)
hippocampus	male	PND 4	↓ GAD1 mRNA	Zhang et al. (2010)
			↓ NGFI-A, CBP, NAB1, NAB2 and Sp1 protein	Hellstrom et al. (2012)
	male	PND 6	↑ Nr3c1 DNA methylation	Weaver et al. (2004)
			↓ GR mRNA and protein; ↓CBP, H3K9Ac and NGFI-A binding to the Nr3c1 promoter	Weaver et al. (2007)
			↓ MBD2 mRNA	Weaver et al. (2014)
	male	PND 8	↓ BDNF mRNA; ↓ NR2A, ↓ NR2B NMDAR subunit mRNA	Liu et al. (2000)
	male	PND 21	↓ neuronal survival; ↑ apoptosis; ↓ bFGF	Bredy et al. (2003)
			↑ Nr3c1 DNA methylation	Weaver et al (2004)
			↓ BDNF mRNA (exon IX)	van Hasselt et al. (2012)
	male	PND 18	↓ synaptophysin, ↓NCAM protein; ↓ NR2A, ↓ NR2B NMDAR subunit mRNA	Liu et al. (2000)
	male	PND 40	↓5-HT turnover	Sequeira-Cordero et al. (2013)
VTA	female	PND 6	↓ TH-IR ↓ cdkn1c mRNA	Pẽna et al. (2014)
	female	PND 21	↓ Lmx1b mRNA	Pẽna et al. (2014)
	female	PND 40	↓ TH-IR	Pẽna et al. (2014)