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. Author manuscript; available in PMC: 2017 Feb 20.
Published in final edited form as: Leuk Res. 2015 Aug 20:S0145-2126(15)30360-X 10.1016/j.leukres.2015.08.007. doi: 10.1016/j.leukres.2015.08.007

Figure 6. ER-stress-induced downregulation of Mcl-1 expression is controlled by a translational mechanism mediated by the UPR PERK/p-eIF2α pathway.

Figure 6

Western blots of Mcl-1 and UPR proteins (GRP78, p-eIF2α (S51), and CHOP) in SUPB15 cells treated with ER-stressors (2-DG, 4 mM; TUN, 2μg/ml) ± PERK inhibitor (GSKA, 200nM) for 24 h. β-actin was used as a loading control.