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. 2015 Dec 21;15(2):267–278. doi: 10.1111/acel.12433

Figure 4.

Figure 4

Expression of the HGPS mutation impairs development‐specific alternative splicing. (A–B) PCA mapping of keratinocyte exon arrays from HGPS mice and their wild‐type littermate controls shows that no major differences are observed after the expression of progerin for 24 days. The main difference is observed between 24‐ and 35‐day‐old animals (A) and secondarily between wild‐type and HGPS mice at 35 days of age (B). (C) The number of AS genes with an FDR‐adjusted alt‐splice P‐value <0.05 in wild‐type and HGPS mice during the 24‐ to 35‐day developmental period (age) is reduced upon expression of the HGPS mutation. (D) The number of AS genes between wild‐type and HGPS is higher at postnatal day 35 compared to postnatal day 24. (E) IPA network and main associated network functions of 377 AS genes between 35‐day‐old HGPS mice and their wild‐type littermates.