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. 2015 Dec 21;15(2):267–278. doi: 10.1111/acel.12433

Figure 5.

Figure 5

Increased numbers of differentially expressed genes in aging wild‐type and HGPS mice. Number of DE genes (DEGs) with FDR‐adjusted P‐value <0.05 and 2‐fold change in gene expression. (A) Distribution of DEGs in the early aging period (4–18 months) by tissue type and across 5 tissues shows a tissue‐specific expression pattern with muscle presenting the highest number of DEGs, but no DEGs in white adipose tissue (WAT). (B) Comparison of DEGs in the muscle between all age groups. (C) Comparison of DEGs in the bone between all age groups. (D) Comparison of DEGs in the skin between all age groups. (E) Mean numbers of DEGs in muscle, bone, and skin show a significant increase in the number of DEGs in the longest aging period (4–28 months) compared to the earlier aging period (4–18 months). (F) Comparison of DEGs between HGPS and wild‐type littermates shows almost no DEGs at postnatal day 24 compared to postnatal day 35. *P < 0.05: two‐tailed, unpaired t‐test, the data are expressed as the means ± SEM.