Figure 4.

Effect of age (2, 6, and 18 months) (A–G) and enriched environment (H–L) on the number of cells expressing doublecortin (Dcx) in the SGZ of WT and Pparα^−/− (KO) mice. The data were expressed as the media of the number of Dcx+ cells per area (mm²) + s.e.m (N = 5). Bonferroni's test: ^*P < 0.05 vs. WT 2M group or WT 18M SE group; ^#P < 0.05 vs. WT 6M group; ^$$P < 0.01 vs. KO 2M group. (B–G) Representative photomicrographs showing low and high (insets) magnification views of the Dcx+ cells in the SGZ of 2, 6, and 18 months old WT and KO mice. (I–L) Representative microphotographs showing low and high (insets) magnification views of the Dcx+ cells in the SGZ of 18 months old WT and KO mice in a standard (SE) or enriched (EE) environment. Scale bars (100 μm and 40 μm for insets) are included in each image.