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. 2016 Mar 9;10:37. doi: 10.3389/fncel.2016.00037

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Copyright © 2016 Nguyen, Rymar and Sadikot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TrkB activation and signal transduction is impaired in R6/2 striatal cultures. (A) Sample immunoblots of TrkB and Erk1/2 signaling proteins from WT and R6/2 cultures after exposure to control (−) or 100 ng/mL BDNF (+) supplemented media. (B) fl-TrkB and (C) Erk1/2 levels are similar in control treated WT (n = 6) and R6/2 (n = 5) cultures. BDNF treatment did not change the levels of these proteins. (D) p-TrkB and (E) p-Erk1/2 levels after treatment with saline or BDNF. BDNF treatment increased p-TrkB and p-Erk1/2 levels to a greater extent in WT (n = 6) compared to R6/2 (n = 5) cultures. Relative protein levels were determined by normalization to the neuronal specific cytoskeleton protein β-tubulin. Unpaired Student’s t-test *p < 0.05.