Table 2.

VMAT2 binding estimates with accompanying β cell function (stimulated AUC c-peptide and peak c-peptide) measurements

Controls-cross-sectional	β cell function		Pancreas body and taila
	AUCb	Peakc	PET ROI volume (ml)	Mean BPND	BPND × volume (ml)d
Subject study number
3001	347	4.9	50.5	1.97	99
3002	550	5.6	38.3	1.65	63
3004	557	7.7	83.3	2.92	243
3005	463	4.9	42.1	2.4	101
3006	372	4.1	53.5	1.79	96
3007	1056	14.0	49.7	2.25	112
3008	572	7.7	48.3	2.45	118
3009	558	6.4	43.5	2.12	92
3010	864	11.6	30.2	1.84	56
Controls-test-retest
4001 teste	57	0.79
4001 retest			22.4	2.644	59.4
4002 test	268	4.4	29.7	2.93	87
4002 retest			32.4	3.08	100
4004 test	407	9.0	32.3	3.18	103
4004 retest			27.6	2.95	81
4005 test	313	8.3	34.3	2.99	103
4005 retest			28.4	2.71	77
4006 test	104	1.2	27.0	2.67	72
4006 retest			30.7	2.97	91
T1DM-cross-sectional
T1D-3001	0.50	0.1	24.3	1.17	29
T1D-3002	0.50	0.1	27.5	1.43	39
T1D-3004	0.50	0.1	26.5	1.85	49
T1D-3005	0.50	0.1	16.3	1.32	22
T1D-3006	0.50	0.1	32.3	1.09	35
T1D-3007	0.5	0.1	14.5	1.86	27
T1DM-test-retest
T1D-4007 test	68	0.74	13.2	2.22	29
T1D-4007 retest			12.3	2.62	32
T1D-4008 test	49	.64	22.8	3.09	71
T1D-4008 retest			24.5	2.89	71
T2DM-cross-sectional
T2D-3001	393	4.52	19.2	1.66	32
T2D-3002	623	4.06	36.2	2.76	100
T2D-3003	1128	9.06	35.4	1.37	49

^aAs defined in Fig. 1

^bAUC insulin c-peptide (ng/ml × minutes)

^cPeak insulin c-peptide concentration (ng/ml) taken from highest serum value from the serial blood draws following the mixed meal stimulus (MMTT).

^dAlso referred to in the text as the functional binding capacity

^eSubject did not successfully complete the first scan. These data used only in Fig. 3