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Proposed model of the GAP complex configuration in ON-bipolar neurons. Cytosolic domains of GPR179 that comprise intracellular loops and coiled-coil containing RGS binding motif directly interact with SNARE-like intracellular domain of R9AP. R9AP binds exclusively to RGS11/Gβ5, and GPR179 binds exclusively to RGS7/Gβ5. Both protein complexes facilitate GTP hydrolysis on Gαo promoting its deactivation.
