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. 2016 Mar 9;36(10):2926–2944. doi: 10.1523/JNEUROSCI.2513-15.2016

Figure 3.

Figure 3.

Dorsal and ventral neural progenitor populations are normal in Dp16. A, A′, Immunohistochemistry labeling apical (aPC, Sox2+, green) and basal intermediate progenitors (bIPC, Tbr2+, red) in euploid (A) and Dp16 (A′) E14.5 neocortex (DAPI, blue). B, C, Each cell population contains normal numbers in the Dp16 neocortical germinal zone at all ages studied. D, Spatial distributions of aPC and bIPCs are normal at all embryonic ages in Dp16 (E13.5 shown, E14.5–18.5 not shown; E13.5: u = 8, Dp = 5; E14.5: Eu = 7, Dp = 5; E15.5: Eu = 9, Dp = 7; E16.5: Eu = 5, Dp = 5; E18.5: Eu = 8, Dp = 8). E, F, Number of Olig2+ progenitors (green) in the E14.5 medial ganglionic eminence in the ventral germinal zone is normal in Dp16 animals. In each graph, the data points and bars represent the mean ± SEM.