Figure 1.

Cdk5 activity is required for the ability of dbcAMP to overcome inhibition by MAG. A, Representative images of CGNs treated with 1 mm dbcAMP and 10 μm roscovitine and plated on monolayers of control or MAG-expressing CHO cells. B, Representative images of DRG neurons treated with 1 mm dbcAMP and 10 μm roscovitine plated on monolayers of control or MAG-expressing CHO cells. Scale bars: A, 20 μm; B, 30 μm. C, Neurite outgrowth was measured from a minimum of 200 neurons for each treatment. Graphs represent the average length of the longest neurite per neuron (depicted as percentage of control) ± SEM. ***p < 0.001.