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. 2015 Sep 22;43(20):9978–9993. doi: 10.1093/nar/gkv923

Table 1. mir-58 family affects body size differently and independently of TGF-β Sma/Mab.

Genotype % length ± 95% CI N P
N2 100 ± 0.7 139
mir-81&mir-82(nDf54) 100.3 ± 1.4a 89 0.56a
mir-80(nDf53) 98.6 ± 1.0a 79 0.19a
mir-80(nDf53);mir-81&mir-82(nDf54) 99.8 ± 1.2a 48 0.12a
mir-58(n4640) 87.8 ± 0.9a 130 <0.001a
mir-58(n4640);mir-81&mir-82(nDf54) 82.2 ± 1.6a 52 0.20c
mir-58(n4640);mir-80(nDf53) 78.5 ± 1.0a 49 <0.001c
mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54) 60.4 ± 1.2a 49 <0.001c,d,e
dbl-1(nk3) 63.8 ± 1.1a 40 0.33f
mir-58(n4640);dbl-1(nk3) 49.5 ± 1.1a 39 <0.001c,g
ctIs40(dbl-1++) 114.2 ± 2.3a 36
mir-58(n4640);ctIs40(dbl-1++) 105.8 ± 2.8a 20 0.002h
mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54);vector(RNAi) 100 ± 1.0 90
mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54);sma-6(RNAi) 76.9 ± 1.2b 73 <0.001i
mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54);daf-4(RNAi) 96.0 ± 1.3b 30 <0.001i
N2 (bis) 100 ± 1.5 39
sma-6(wk7) 67 ± 1.9j 58 <0.001j
sma-6(wk7);sma-6::3'UTR sma-6 WT 105.0 ± 2.1j 50 <0.001j
sma-6(wk7);sma-6::3UTR sma-6 MUT 112.1 ± 1.4j 50 <0.001j,k
mir-58f(-) 100 ± 1.9 40
mir-58f(-);sma-6::3UTR sma-6 WT 111.0 ± 2.1l 60 <0.001l
mir-58f(-);sma-6::3UTR sma-6 MUT 108.8 ± 1.4l 40 <0.001l,
0.486m

N number of measured worms.

aCompared to N2.

bReferred to the length of mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54) treated with RNAi empty vector.

cCompared to mir-58(n4640).

dCompared to mir-58(n4640);mir-81&mir-82(nDf54).

eCompared to mir-58(n4640);mir-80(nDf53).

fCompared to mir-58(n4640);mir-80(nDf53);mir-81&mir-82(nDf54).

gCompared to dbl-1(nk3).

hCompared to ctIs40(dbl-1++).

iCompared to empty vector (RNAi).

jCompared to N2 (bis).

kCompared to sma-6(wk7);sma-6::3UTR sma-6 WT.

lCompared to mir-58f(-).

mCompared to mir-58f(-);sma-6::3UTR sma-6 WT.