Table 1.
ED50 and confidence limits of HEPP and its fluorinated and chlorinated derivatives against MES and PTZ.
| Treatments | MES mg/kg |
C.L. 95% |
PTZ mg/kg |
C.L. 95% |
|---|---|---|---|---|
| HEPP | 129.6 | 14% to 70% | 66.4 | 14% to 70% |
| F-HEPP | 87.1 | 14% to 70% | 43.5 | 14% to 70% |
| Cl-HEPP | 62.0 | 14% to 70% | 43.5 | 22% to 78% |
| Sodium valproate | 261.2 | 14% to 70% | 159.7 | 22% to 78% |
| Phenobarbital | 16.3 | 30% to 86% | 12.7 | 14% to 70% |
MES: maximal electroshock; PTZ: pentylenetetrazole; HEPP: 3-hydroxy-3-ethyl-3-phenylpropionamide; F-HEPP: 3-hydroxy, 3-ethyl, 3-(4′-fluorophenyl)propioanamide; Cl-HEPP: 3-hydroxy, 3-ethyl, 3-(4′-chlorophenyl)propionamide; C.L.: confidence limits of the expected fraction.