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. 2016 Mar 9;7:90. doi: 10.3389/fimmu.2016.00090

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Copyright © 2016 Jansen, van Herwijnen, van Kooten, Hoek, van der Zee, van Eden and Broere.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mB29b-TCR transgenic mouse shows no pathological changes in histology. (A) Thymus, inguinal lymph nodes (iLN), and liver (data not shown) were isolated from mB29b-TCR positive mice, or negative littermates. (A) shows sections of the spleen in which no structural changes were observed between the mB29b-TCR transgenic mouse and the non-transgenic littermate. Immunohistochemistry was performed to T cells (αCD3) and general proliferation in lymphoid tissues. The distribution of CD3⁺ T cells in the mB29b-TCR transgenic mouse does not deviate from the non-transgenic littermate. Pictures show the spleen in a 4× magnification. (B) Splenocytes were isolated from naive wild type Balb/c, mB29b TCR Tg mice and negative littermates and CD4⁺ cells were stained for KI-67 or CD44 and CD62L. Data are obtained by flow cytometry. Data are shown as mean of triplicate samples/well ± SEM. Data shown are representative of two independent experiments.