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. 2016 Mar 15;67(10):1200–1210. doi: 10.1016/j.jacc.2015.12.060

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© 2016 Elsevier Inc. All rights reserved.

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Central Illustration — Metabolomic Profiling of Statin Therapy: Longitudinal Cohorts and an HMGCR Gene Variant Mimicking the Statin Effect

As assessed from longitudinal cohorts and an HMGCR gene variant mimicking the effect of statins, widespread lipid-lowering occurs beyond low-density lipoprotein cholesterol (LDL-C), but there is minimal evidence for similar effects on non-lipid metabolites. Blue diamonds represent longitudinal metabolic changes associated with starting statins. Orange diamonds represent metabolic associations with rs12916 in HMGCR, denoting the causal effects of HMGCR inhibition. Association magnitudes are relative to the lowering effect on LDL-C. CI = confidence interval.