Table 1.
Baseline Characteristics
| Southall and Brent REvisited (SABRE) Study |
Pieksämäki Cohort Study |
Cardiovascular Risk in Young Finns Study |
Avon Longitudinal Study of Parents and Children (Mothers) |
|||||
|---|---|---|---|---|---|---|---|---|
| Nonusers (n = 372) |
Starters (n = 536) |
Nonusers (n = 562) |
Starters (n = 106) |
Nonusers (n = 1,519) |
Starters (n = 43) |
Nonusers (n = 2,421) |
Starters (n = 31) |
|
| Follow-up time, yrs | 20–23 | 6–7 | 4–5 | 2–3 | ||||
| Male | 84 | 89 | 41 | 43 | 44 | 63 | 0 | 0 |
| Age, yrs | 48.5 ± 6.1 | 50.3 ± 6.3 | 45.4 ± 6.2 | 48.5 ± 5.4 | 37.9 ± 5.0 | 40.7 ± 4.0 | 48.2 ± 4.3 | 50.7 ± 4.8 |
| BMI, kg/m2 | 25.1 ± 3.1 | 26.3 ± 3.6 | 26.1 ± 4.1 | 27.9 ± 6.2 | 25.8 ± 4.6 | 28.9 ± 5.9 | 26.0 ± 4.9 | 28.2 ± 4.5 |
| Systolic blood pressure, mm Hg | 117 ± 15 | 124 ± 16 | 134 ± 18 | 138 ± 18 | 120 ± 14 | 129 ± 13 | 118 ± 12 | 128 ± 17 |
| Plasma glucose, mmol/l | 5.3 (4.9–5.7) | 5.5 (5.1–5.9) | 5.6 (5.3–6.0) | 5.8 (5.5–6.3) | 5.2 (4.9–5.6) | 5.4 (5.2–5.8) | 5.1 (4.9–5.4) | 5.3 (5.1–5.8) |
| HDL cholesterol, mmol/l | 1.3 ± 0.3 | 1.2 ± 0.3 | 1.4 ± 0.3 | 1.4 ± 0.3 | 1.3 ± 0.3 | 1.2 ± 0.4 | 1.5 ± 0.4 | 1.3 ± 0.4 |
| Friedewald LDL cholesterol, mmol/l | 3.6 ± 0.9 | 4.1 ± 1.0 | 3.5 ± 0.8 | 4.3 ± 0.9 | 3.1 ± 0.8 | 4.1 ± 0.8 | 3.0 ± 0.8 | 4.1 ± 1.3 |
| Total cholesterol, mmol/l | 5.6 ± 1.0 | 6.3 ± 1.1 | 5.5 ± 0.9 | 6.4 ± 0.9 | 5.0 ± 0.9 | 6.0 ± 0.9 | 4.9 ± 0.8 | 6.1 ± 1.4 |
| Triglycerides, mmol/l | 1.2 (0.9–1.7) | 1.7 (1.2–2.5) | 1.1 (0.8–1.6) | 1.4 (1.1–2.0) | 1.1 (0.8–1.6) | 1.6 (1.1–2.3) | 0.8 (0.7–1.1) | 1.3 (1.0–2.0) |
Values are %, mean ± SD, or median (interquartile range), unless otherwise indicated. Characteristics of the 8 population-based cohorts used for genetic analyses are shown in Online Table 2.
BMI = body mass index; HDL = high-density lipoprotein; LDL = low-density lipoprotein.