Table 1.
Pathway analysis of significant metabolite features for the baseline compared with purified diet, NE compared with purified diet, and return to NE compared with purified diet
| Baseline vs purified diet | Overlap size | Pathway size | Enrichment P | Model P | ||
| Glycine, serine, alanine, and threonine metabolism | 10 | 27 | 0.1085 | 0.0030 | ||
| Aspartate and asparagine metabolism | 14 | 33 | 0.0188 | 0.0014 | ||
| Lysine metabolism | 8 | 16 | 0.0256 | 0.0016 | ||
| Valine, leucine, and isoleucine degradation | 6 | 17 | 0.2317 | 0.0087 | ||
| Methionine and cysteine metabolism | 5 | 18 | 0.4807 | 0.0373 | ||
| Carnitine shuttle | 7 | 14 | 0.0366 | 0.0019 | ||
| NE diet vs purified diet | ||||||
| Glycine, serine, alanine, and threonine metabolism | 10 | 27 | 0.0085 | 0.0009 | ||
| Aspartate and asparagine metabolism | 8 | 33 | 0.1763 | 0.0042 | ||
| Lysine metabolism | 6 | 16 | 0.0381 | 0.0014 | ||
| Valine, leucine and isoleucine degradation | 7 | 17 | 0.0146 | 0.0010 | ||
| Methionine and cysteine metabolism | 5 | 18 | 0.1720 | 0.0055 | ||
| Carnitine shuttle | 4 | 14 | 0.1980 | 0.0083 | ||
| Return to NE diet vs purified diet | ||||||
| Glycine, serine, alanine and threonine metabolism | 11 | 27 | 0.0017 | 0.0017 | ||
| Aspartate and asparagine metabolism | 11 | 33 | 0.0104 | 0.0019 | ||
| Lysine metabolism | 6 | 16 | 0.0319 | 0.0027 | ||
| Valine, leucine and isoleucine degradation | 6 | 17 | 0.0429 | 0.0031 | ||
| Methionine and cysteine metabolism | 4 | 18 | 0.3313 | 0.0322 | ||
| Carnitine shuttle | 4 | 14 | 0.1785 | 0.0125 | ||