Skip to main content
. 2015 Nov 10;65(1):53–62. doi: 10.1538/expanim.15-0062

Fig. 3.

Fig. 3.

Indication and identification of a retained unlinked locus in the BALB/c-congenic ANP32B-deficient heterozygotes. (A) Histogram of Anp32b−/− mice provision from individual breeding pairs of six-generation BALB/c-congenic colony. (B) Strain-specific SNP mapping of representative Anp32b heterozygotes indicates two regions of C57BL/6J retention on chromosomes 4 and 11 in the six-generation BALB/c-congenic mice. The retained locus on chromosome 4 surrounds Anp32b. (C) Genes in the region of the retained C57BL/6J SNP rs6190775 demonstrated different degrees of exonic mutation between the strains. The heavily bolded line indicates the region of C57BL/6 retention for animals used in exome sequencing as part of SNP homozygosity breeding. SNP, single-nucleotide polymorphism; Indel, insertion/deletion mutations.