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Mean (± SE) respiratory frequency (breaths/min) in Sprague Dawley rats (n=6/age group; 3, 6, 12, and 18 months old) following an intraperitoneal administration of 80 mg/kg of ketamine and 10 mg/kg xylazine. The respiratory frequency was measured by direct observation at 5, 15, 30, 45, 60, 90, and 120 min, and measurement ended when all animals had a positive withdrawal reflex. No significant difference between groups.
