Table 2. Mean (SD) biochemistry parameters following a single intraperitoneal injection of ketamine (80 mg/kg) and xylazine (10 mg/kg) administered to male Sprague Dawley rats (n=3/group) of different ages.
Biochemistry parameters (units) | Normal values | Age (months) | |||
---|---|---|---|---|---|
3 | 6 | 12 | 18 | ||
Glucose (mmol/l) | 4.4–16.7 | 9.3 (1.3) | 12.9 (3.2) | 17.6 (6.0) | 28.8 (9.0) |
BUN (mmol/l) | 3.9–8.2 | 9.6 (1.1) | 9.9 (1.7) | 11.8 (1.8) | 13.0 (2.3) |
Creatinine (mmol/l) | 35–123 | 40.0 (3.5) | 45.3 (5.8) | 58.7 (8.3) | 65.7 (16.0) |
ALT (U/l) | 28–40 | 55.7 (9.2) | 48.7 (9.0) | 56.0 (15.9) | 62.0 (7.2) |
ALP (U/l) | 150–220 | 215.3 (53.4) | 138.0 (28.2) | 142.3 (23.7) | 164.7 (35.3) |
Total proteins (g/l) | 58–66 | 64.6 (0.6) | 61.1 (1.0) | 56.1 (6.1) | 59.4 (7.2) |
Albumin (g/l) | 33–46 | 32.8 (0.3) | 31.5 (1.8) | 28.3 (2.6) | 28.3 (3.9) |
Globulins (g/l) | 17–30 | 31.8 (0.6) | 29.6 (1.8) | 27.8 (3.6) | 31.1 (1.3) |
ALP, alkaline phosphatase; ALT, alanine aminotransferase; BUN, blood urea nitrogen.