Table 1. Risk of cancer of unknown primary for offspring with first degree relatives diagnosed with cancer.
| Cancer in relatives | Parental only |
Sibling only |
Parent and sibling |
First degree relatives |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| O | SIR | 95%CI | O | SIR | 95%CI | O | SIR | 95%CI | O | SIR | 95%CI | |||||
| Upper aerodigestive tract | 146 | 1.33 | 1.12 | 1.56 | 58 | 1.12 | 0.85 | 1.44 | 2 | 1.94 | 0.18 | 7.13 | 206 | 1.26 | 1.10 | 1.45 |
| Esophagus | 52 | 1.28 | 0.95 | 1.68 | 23 | 1.28 | 0.81 | 1.92 | 1 | 7.22 | 0.00 | 41.39 | 76 | 1.29 | 1.02 | 1.62 |
| Stomach | 239 | 0.96 | 0.84 | 1.09 | 44 | 1.13 | 0.82 | 1.51 | 3 | 1.31 | 0.25 | 3.87 | 286 | 0.98 | 0.87 | 1.10 |
| Colorectum | 564 | 0.96 | 0.88 | 1.04 | 237 | 1.12 | 0.98 | 1.26 | 24 | 1.83 | 1.17 | 2.63 | 825 | 1.01 | 0.95 | 1.08 |
| Colon | 347 | 0.92 | 0.83 | 1.02 | 134 | 1.03 | 0.87 | 1.23 | 18 | 1.78 | 1.05 | 2.81 | 499 | 0.97 | 0.88 | 1.05 |
| Rectum | 217 | 1.02 | 0.89 | 1.16 | 103 | 1.25 | 1.02 | 1.51 | 6 | 1.98 | 0.71 | 4.35 | 326 | 1.09 | 0.98 | 1.22 |
| Liver | 177 | 1.14 | 0.98 | 1.33 | 54 | 1.40 | 1.05 | 1.83 | 4 | 3.94 | 1.03 | 10.19 | 235 | 1.21 | 1.06 | 1.38 |
| Pancreas | 152 | 1.01 | 0.85 | 1.18 | 54 | 1.19 | 0.90 | 1.56 | 4 | 2.87 | 0.75 | 7.42 | 210 | 1.06 | 0.92 | 1.22 |
| Lung | 404 | 1.19 | 1.07 | 1.31 | 284 | 1.71 | 1.52 | 1.92 | 25 | 2.43 | 1.57 | 3.59 | 713 | 1.38 | 1.28 | 1.48 |
| Breast | 484 | 1.00 | 0.91 | 1.10 | 435 | 1.17 | 1.06 | 1.29 | 35 | 1.10 | 0.77 | 1.53 | 954 | 1.08 | 1.01 | 1.15 |
| Cervix | 103 | 1.09 | 0.89 | 1.33 | 44 | 1.09 | 0.79 | 1.46 | 0 | 147 | 1.09 | 0.92 | 1.28 | |||
| Endometrium | 125 | 0.96 | 0.80 | 1.15 | 68 | 0.99 | 0.77 | 1.26 | 2 | 1.10 | 0.10 | 4.04 | 195 | 0.97 | 0.84 | 1.12 |
| Ovary | 121 | 1.12 | 0.93 | 1.34 | 62 | 1.07 | 0.82 | 1.37 | 5 | 3.41 | 1.08 | 8.03 | 188 | 1.12 | 0.97 | 1.30 |
| Prostate | 706 | 1.05 | 0.98 | 1.13 | 361 | 1.07 | 0.96 | 1.19 | 48 | 0.91 | 0.67 | 1.21 | 1115 | 1.05 | 0.99 | 1.12 |
| Kidney | 171 | 1.11 | 0.95 | 1.29 | 69 | 1.22 | 0.95 | 1.54 | 3 | 1.96 | 0.37 | 5.81 | 243 | 1.14 | 1.00 | 1.30 |
| Urinary bladder | 264 | 1.12 | 0.99 | 1.26 | 104 | 1.14 | 0.93 | 1.39 | 3 | 0.75 | 0.14 | 2.21 | 371 | 1.12 | 1.01 | 1.24 |
| Melanoma | 114 | 1.11 | 0.92 | 1.33 | 126 | 1.08 | 0.90 | 1.28 | 4 | 1.43 | 0.37 | 3.70 | 244 | 1.10 | 0.96 | 1.24 |
| Skin, squamous cell | 209 | 0.96 | 0.83 | 1.10 | 69 | 1.04 | 0.81 | 1.32 | 3 | 0.91 | 0.17 | 2.68 | 281 | 0.98 | 0.87 | 1.10 |
| Nervous system | 127 | 1.08 | 0.90 | 1.29 | 95 | 1.03 | 0.83 | 1.26 | 1 | 0.52 | 0.00 | 3.01 | 223 | 1.05 | 0.92 | 1.20 |
| Thyroid gland | 42 | 1.24 | 0.90 | 1.68 | 24 | 1.02 | 0.65 | 1.52 | 0 | 66 | 1.15 | 0.89 | 1.46 | |||
| Endocrine glands | 76 | 1.06 | 0.83 | 1.32 | 54 | 1.10 | 0.83 | 1.44 | 1 | 1.36 | 0.00 | 7.80 | 131 | 1.08 | 0.90 | 1.28 |
| Connective tissue | 29 | 0.97 | 0.65 | 1.39 | 31 | 1.91 | 1.30 | 2.71 | 1 | 11.33 | 0.00 | 64.92 | 61 | 1.32 | 1.01 | 1.69 |
| Non-Hodgkin lymphoma | 185 | 1.00 | 0.86 | 1.16 | 104 | 1.05 | 0.86 | 1.28 | 2 | 0.54 | 0.05 | 1.98 | 291 | 1.01 | 0.90 | 1.14 |
| Myeloma | 85 | 1.10 | 0.88 | 1.36 | 25 | 0.90 | 0.58 | 1.33 | 1 | 1.62 | 0.00 | 9.27 | 111 | 1.05 | 0.86 | 1.27 |
| Leukemia | 95 | 1.08 | 0.87 | 1.32 | 44 | 1.04 | 0.76 | 1.40 | 0 | 139 | 1.06 | 0.89 | 1.26 | |||
| CUP | 189 | 1.07 | 0.93 | 1.24 | 85 | 1.40 | 1.12 | 1.73 | 0 | 274 | 1.15 | 1.02 | 1.30 | |||
| All | 3188 | 0.99 | 0.96 | 1.03 | 1133 | 1.09 | 1.02 | 1.15 | 172 | 1.24 | 1.06 | 1.43 | 5506 | 1.05 | 1.02 | 1.08 |
O = observed number of cases in offspring. Bolding shows that the 95% confidence limits (95%CI) do not include 1.00.