Table 4. Risk of cancer in offspring with parents diagnosed with cancer of unknown primary with defined extranodal metastases.

Cancer	All				Abdomen				Liver				Head & neck				Thorax
	O	SIR	95%CI		O	SIR	95%CI		O	SIR	95%CI		O	SIR	95%CI		O	SIR	95%CI
Upper aerodigestive tract	95	1.13	0.91	1.38	20	0.93	0.57	1.44	13	0.72	0.38	1.23	7	2.56	1.02	5.31	8	1.10	0.47	2.17
Esophagus	30	1.08	0.73	1.55	5	0.71	0.22	1.66	8	1.36	0.58	2.68	2	2.41	0.23	8.85	3	1.26	0.24	3.74
Stomach	34	0.67	0.46	0.94	6	0.47	0.17	1.02	8	0.76	0.32	1.50	0				2	0.49	0.05	1.80
Colorectum	375	1.24	1.12	1.37	90	1.16	0.94	1.42	82	1.30	1.03	1.60	10	1.10	0.53	1.89	34	1.37	0.95	1.87
Colon	236	1.28	1.12	1.45	59	1.25	0.95	1.62	52	1.35	1.01	1.77	8	1.44	0.61	2.85	20	1.33	0.81	2.05
Rectum	139	1.18	0.99	1.39	31	1.03	0.70	1.47	30	1.22	0.82	1.74	2	0.57	0.05	2.08	14	1.44	0.78	2.42
Liver	58	1.08	0.82	1.40	10	0.73	0.35	1.35	15	1.33	0.74	2.21	3	1.84	0.35	5.44	7	1.56	0.62	3.23
Lung	287	1.28	1.13	1.43	80	1.39	1.10	1.73	52	1.10	0.82	1.44	10	1.51	0.72	2.80	21	1.08	0.67	1.65
Breast	786	1.08	1.01	1.16	207	1.12	0.97	1.28	165	1.08	0.92	1.26	23	1.00	0.63	1.50	63	1.06	0.81	1.36
Endometrium	120	1.15	0.96	1.38	21	0.79	0.49	1.21	21	0.98	0.61	1.50	6	2.11	0.76	4.63	16	1.89	1.08	3.08
Ovary	106	1.24	1.02	1.51	38	1.77	1.25	2.43	29	1.64	1.10	2.36	2	0.77	0.07	2.84	10	1.47	0.70	2.71
Prostate	636	1.20	1.11	1.30	162	1.18	1.01	1.38	138	1.24	1.04	1.47	22	1.43	0.89	2.16	69	1.51	1.18	1.91
Kidney	101	1.27	1.03	1.54	25	1.24	0.80	1.83	18	1.08	0.64	1.71	7	2.90	1.15	6.02	8	1.24	0.53	2.45
Urinary bladder	130	1.08	0.90	1.28	31	1.01	0.68	1.43	27	1.06	0.70	1.55	5	1.39	0.44	3.27	11	1.08	0.53	1.93
Nervous system	192	1.16	1.00	1.33	51	1.24	0.92	1.63	46	1.33	0.97	1.77	7	1.21	0.48	2.52	12	0.95	0.49	1.66
CUP	92	1.06	0.86	1.31	15	0.68	0.38	1.13	19	1.05	0.63	1.64	5	1.94	0.61	4.57	10	1.41	0.67	2.61
All	4210	1.14	1.11	1.18	1044	1.12	1.05	1.19	873	1.13	1.06	1.21	153	1.31	1.11	1.54	368	1.22	1.10	1.35