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. 2016 Mar 9;6:22910. doi: 10.1038/srep22910

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Copyright © 2016, Macmillan Publishers Limited

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The ACh-induced relaxation of Phe-precontracted abdominal aortas of ApoE^−/− mice after intravenously injected with vehicle, miR-146a, and miR-181b (15 μg) loaded in PEG/PEI nanoparticles (A) or ESTA-MSV microparticles (B) biweekly for 12 weeks. (C,D) The ACh-induced relaxation of carotid arteries of ApoE^−/− mice treated as above. (E,F) The ACh-induced contraction of carotid arteries of ApoE^−/− mice in the presence of L-NAME (100 μmol/L). Data are shown as the means ± SEM (n = 5). *P < 0.05, **P < 0.01 vs. vehicle group.