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Changes in HER2 expression pattern in matched pre and post CRT samples. Pre-tx (blue), initial diagnostic biopsy; post-tx (red), surgical resection specimen; Neg, HER2 expression 0 or 1+; Indeterminate, HER2 expression 2+; Positive, HER2 expression 3+ by IHC. HER2, human epidermal growth factor receptor 2; CRT, chemoradiotherapy; pCR, pathologic complete response; NET, not enough tumor to examine.
