Skip to main content
. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: J Immunol. 2015 Dec 28;196(3):1013–1025. doi: 10.4049/jimmunol.1501570

Figure 10. Retinal lymphoid aggregates contain CD138+/B220+ plasma cells and mice with retinal TLT have elevated serum antibodies to peptide 161-180 of the IRBP protein.

Figure 10

A–J. CD138+ cells (red) in well-defined retinal TLT under high magnification (40x). White arrows represent CD138+/B220+ cells under 40x magnification. K. ELISA analysis of serum auto-antibodies specific to the IRBP peptide 161-180 from R161H mice with and without retinal TLT structures. The positive control is wild-type B10.RIII mice immunized with the IRBP peptide 161-180. There is a significantly higher serum concentration of IRBP specific auto-antibodies in the mice with retinal TLT aggregates compared to mice without retinal TLT aggregates (*p<0.05). ELISA was repeated three times on five different mice from each group with consistent results. P values were determined using Student’s t test.