Table 3.
Targets and functions in breast cancer of housekeeper candidates.
| MicroRNA | Variation * | Targets | Function | References |
|---|---|---|---|---|
| miR-16-5p | down-regulated | FEAT (faint expression in normal tissues, aberrant overexpression in tumors) | Tumor, suppressor | [31,32,33] |
| CCND1 (Cyclin D1) | ||||
| BCL2 (B-cell lymphoma 2) | ||||
| RPS6KB1 (Ribosomal protein S6) | ||||
| miR-29a-3p | up-regulated | TTP (tristetraprolin) | MetastamiR, OncomiR (drug resistance) | [34,35] |
| PTEN | ||||
| miR-126-3p | down-regulated | VEGF | Tumor, suppressor, MetastamiR | [36,37,38,39,40,41] |
| PIK3R2 (phosphoinositide-3-kinase regulatory subunit 2) | ||||
| IRS-1 (Insulin receptor substrate 1) | ||||
| adapter molecule Crk | ||||
| SDF-1α (stromal cell-derived factor-1 alpha) | ||||
| KRAS | ||||
| miR-222-3p | up-regulated | ERα | OncomiR (drug resistance) | [35,42,43] |
| p27Kip1 (cyclin-dependent kinase inhibitor 1B) | ||||
| p57 (cyclin-dependent kinase inhibitor 1C) | ||||
| TIMP3 (tissue inhibitor of metalloproteinase-3) |
* As compared with normal tissue or parental cell lines in case of preclinical data.