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. 2016 Feb 2;17(2):199. doi: 10.3390/ijms17020199

Table 3.

Epigenetic regulations of gene expression by DNA binding proteins. Summary of the gene expression regulations by methylated DNA binding proteins, such as polycomb group proteins, heterochromatin proteins and DNA binding zinc finger proteins.

Molecules Regulate Gene Expression Type of Modification Examples Outcomes
DNA-binding proteins Methylation Polycomb group proteins (PcG) Play a role in cellular differentiation by repressing transcription [41].
Heterochromatin protein (HP1) Include many functions, like repressing genes by heterochromatin formation, regulates binding of complexes to centromere and maintains chromatin integrity [42].
DNA binding zinc finger protein (ZnF) Regulates transcription processes, such as C2H2 ZnFs [43].