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. 2016 Feb 5;17(2):212. doi: 10.3390/ijms17020212

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic structure and sequence alignment of human CIZ1 protein. (a) Schematic illustration of CIZ1 protein. The glutamine rich region (QR1 and QR2), nuclear localizing signal (NLS), zinc finger domain (ZF), MH3 domain (MH3), acid domain (AD), and CDK2 targeting sequence are indicated in the diagram; and the (b) amino acid sequence of CIZ1 protein (Accession No. NP_001244904.1). The first 30 amino acid (aa) residues are only predicted but have not been validated [19]. The two glutamine-rich domains are shaded with grey. The three zinc finger motifs are underlined and the acidic domain is double-underlined. The MH3 domain is in bold and italic. The two nuclear localizing signals are boxed. The predicted CDK2 and PIKK phosphorylation sites are indicated by dots and asterisks, respectively.