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. 2016 Feb 5;17(2):213. doi: 10.3390/ijms17020213

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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AAI O-demethylation to AAIa catalyzed by human wild-type CYP1A1, 1A2 and 1B1, and their mutants CYP1A1-S122A, CYP1A2-T124V, and CYP1B1-A133S. All CYPs were reconstituted with rat POR in a ratio of 1:1 in liposomes. Data are averages ± SD of three independent measurements (n = 3). Numbers above columns (“F”) indicate fold changes in O-demethylation of AAI to AAIa catalyzed by wild-type and mutant CYPs. Comparison was carried out by Student t-test; * p < 0.05, *** p < 0.001, different from wild-type CYP enzymes.