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. 2016 Feb 17;17(2):244. doi: 10.3390/ijms17020244

Figure 2.

Figure 2

Expression of various biomarkers for psoriasis is regulated by rERDR1 administration. (a) Expression of hyper-proliferating marker, keratin 6, keratin 14, keratin 16, and antimicrobial peptide, S100A8, was detected by RT-PCR. The Krt1, Krt14, Krt16 and S100a8 mRNAs increased by imiquimod treatment were significantly decreased by rERDR1 administration; (b) Transcription of effector cytokines IL-17 and IL-22 that are produced by Th17 cells and act in psoriasis pathogenesis, as well as the inflammatory cytokine TNF-α, were detected in psoriatic lesional skin tissues. rERDR1 reduced mRNA expression of IL-17, IL-22, and TNF-α; (c) Erdr1 mRNA expression was detected in psoriatic lesional skin tissues. Erdr1 mRNA was significantly decreased following imiquimod treatment, and levels increased following rERDR1 administration. Data shown represent one of three independent experiments.