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Constitutively active-AKT reduced the expression of tyrosinase and MITF. The B16F10 (105) cells were transfected with constitutively active AKT plasmid (5 μg) for 16 h prior to treated with hinokitiol (125 nM) for 48 h. The expression of P-AKT, AKT, m-TOR, P-mTOR, MITF tyrosinase and LC3 protein in B16F10 cells was determined. The inserted values indicate relative protein expression compared to β-actin. This experiment was repeated with similar results. (mean ± SD, n = 3).
