Table 3.
Markov model transition rates (ms−1) for Ranolazine
| Parameter Name | Value |
|---|---|
| kon = kclosed, on | [D+]*Diffusion |
| koff = kclosed, off | kd, open *Diffusion; (kdopen = 100.5e‐6*exp(‐0.7*V*F/R*T)) |
| kbursting, on = kclosed bursting, on | [D+]*Diffusion |
| kbursting, off = kclosed bursting, off | kdBursting,Open *Diffusion; (kdBursting,Open = 1.5012e‐6*exp(‐0.7*V*F/R*T)) |
| kneutral, on | [D]*Diffusion |
| kneutral, off | 400e‐6*Diffusion |
| kneutral, inactivated, on | kneutral, on |
| kneutral, inactivated, off | 5.4e‐6*Diffusion |
| kneutral, closed, on | kneutral, on |
| kneutral, closed, off | 800e‐6*Diffusion |
| Diffusion | 5500 M−1ms−1 |
| States of Markov model | Rate constants |
| D+IC3 →D+IC2, D+C3→D+C2, | α11 |
| DIC3 →DIC2, DC3→DC2 | |
| D+IC2→D+IF, D+C2→D+C1, | α12 |
| DIC2→DIF, DC2→DC1 | |
| D+IC2→D+IC3, D+C2→D+C3, | β11 |
| DIC2→DIC3, DC2→DC3 | |
| D+IF→D+IC2, D+C1→D+C2, | β12 |
| DIF→DIC2, DC1→DC2 | |
| D+O→D+IS | αx1 = 4.4923e+3 *αx |
| D+IS→D+O | βx1 = 2.7031e‐1 *βx |
| DO→DIS | αx2 = 1.4947e+1 *αx |
| D+C1→D+O | α13c = 3.6811*α13 |
| DC1→DO | α13n = 2.3570e+2*α13 |
| D+O→D+C1 | β13c = (β13*kcon*koff*α13c)/(kon*kcoff*α13) |
| DO→DC1 | β13n = (β13*kc_on*α13n*k_off)/(kc_off*α13*k_on) |
| DIS→DO | βx2 = (βx*k_on* αx2*ki_off)/(αx*ki_on*k_off) |
| D+O→D+IF | α22 = 6.8705e+4 *α2 |
| DO→DIF | α_22 = 2.1182e+2 *α2 |
| D+IF→D+O | β22 = (α13c* α22* α33)/(β13c* β33) |
| DIF→DO | β_22 = (α_33*α13n*α_22)/(β_33*β13n) |
| D+C3→D+IC3, D+C2→D+IC2, D+C1→D+IF | β33 = 1.7561e‐1 *β3 |
| DC3→DIC3, DC2→DIC2, DC1→DIF | β_33 = 1.2197e‐3*β3 |
| D+IC3→D+C3, D+IC2→D+C2, D+IF→D+C1 | α33 = 4.0832e‐2 *α3 |
| DIC3→DC3, DIC2→DC2, DIF→DC1 | α_33 = (ki_off* α3*kc_on* β_33)/(ki_on*kc_off* β3) |