Table 1.
Demographics and clinical scores
| Controls (N = 23) | Alzheimer's disease (N = 23) | LBD (N = 32) | Between group differences (P‐value) | Between group post‐hoc tests | |
|---|---|---|---|---|---|
| Age | 76.3 (5.5) | 75.8 (8.2) | 75.0 (6.4) | F 2,75 = 0.25,P = 0.8 | – |
| Sex male:female | 16:7 | 20:4 | 27:5 | χ 2 = 2.0; P = 0.4 | – |
| Duration (years) cognitive decline | – | 3.39 (1.61) | 3.33 (2.07) | T = 1.2; P = 0.9a | – |
| Cholinesterase Inhibitors | 0 (0%) | 25 (100%) | 27 (84%) | Fisher p =0.068a | – |
| Positive DAT scan | – | – | 10/11 (91%) | – | |
| UPDRS | 1.3 (1.7) | 2.0 (1.7) | 19.06 (8.0) | F 2,75 = 102, P < 0.001 | Con = AD « LBD |
| Cornell | 0.59 (1.1) | 0.91 (1.1) | 2.97 (2.2) | F 2,75 = 18, P < 0.001 | Con = AD « LBD |
| MMSE | 29.1 (0.9) | 22.0 (3.2) | 23.4 (3.8) | T = 1.4; P = 0.16a | – |
| CAMCOG | 96.8 (3.6) | 71.0 (11.7) | 76.7 (12.6) | T = 1.7; P = 0.10a | – |
| CAMCOG executive | 23.0 (2.5) | 15.1 (4.1) | 13.3 (4.1) | T = 1.7; P = 0.10a | – |
| MAYO fluctuations | 1.0 (1.0) | 2.35 (1.4) | T = 3.9;P < 0.001a | – | |
| MAYO cognitive | 1.95 (1.9) | 2.71 (1.9) | T = 1.4; P = 0.16a | – | |
| CAF total | – | 0.5 (1.4) | 4.81 (4.1) | T = 4.8; P < 0.001 | – |
| 1 day fluctuation | 2.14 (2.4) | 3.59 (3.1) | T = 1.8; P = 0.08a | – | |
| NPI | 6.2 (6.8) | 13.4 (10.0) | T = 3.0; P = 0.005a | – | |
| Verbal fluency (FAS) | 43.7 (16.2) | 30.1 (15.5) | 20.5 (11.9) | F 2,75 = 17,P < 0.001 | Con » AD › LBD |
| Angle discrimination | 19.7 (0.8) | 19.4 (1.3) | 16.5 (4.7) | F 2,75 = 8.7, P < 0.001 | Con = AD » LBD |
a
Alzheimer's disease vs Lewy body dementia 2 group comparison.
ANOVA Post hoc (Tukey) group comparisons, AD, Alzheimer's disease; Con, controls.
‹ Indicates P < 0.05; « P < 0.01; = indicates P >=0.05.
Abbreviations: CAMCOG, Cambridge Cognitive Examination; MMSE, Mini ‐Mental State Examination; NPI, Neuropsychiatric Inventory; CAF, Clinician Assessment of Fluctuations Scale; UPDRS, Unified Parkinson's disease rating scale; FAS, fluency for words starting with F,A,& S; Cornell, Cornell depression in dementia rating scale.