Figure 2.

Placental ER stress is associated with lower PlGF mRNA levels in pre‐eclamptic placentae. (A) Quantitative real‐time RT–PCR was used to measure transcript levels of PlGF, ATF4, ATF6α and ATF6β in early‐PE, late‐PE and NTC placentae; data are presented as Dot‐plots with median; the differences among early‐PEs, late‐PEs and NTCs was analysed by a non‐parametric Kruskal–Wallis test with Dunn's multiple comparison test; early‐PE, n = 11; late‐PE, n = 8; and NTC, n = 7; *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. (B) The correlation between ATF4 and PlGF mRNA levels was plotted for all placental samples; a power regression line was fitted to display the relationship between the two transcripts; ***p ≤ 0.001