Table 1.

Hypotheses being tested

Objective	Statistic	H0	H1
Interaction Effect	Likelihood Ratio	γjk = 0a	γjk= 0b
Prognostic / Predictive	ΔAUC	AUC1− AUC0 = 0	AUC1− AUC0 ≠ 0
Predictive	RERIjk	$exp\{{\gamma }_{jk}\}=\frac{exp\{{\beta }_j\}+exp\{{\delta }_k\}-1}{exp\{{\beta }_j+{\delta }_k\}}$	$exp\{{\gamma }_{jk}\}\ne \frac{exp\{{\beta }_j\}+exp\{{\delta }_k\}-1}{exp\{{\beta }_j+{\delta }_k\}}$

^afor all j and k in Equation (1)

^bfor at least one j and k in Equation (1)