Table 1.

Comparison with control group

Response	Drug	Dose	Mean	SD	P
MMP-1	B	10	1.9	0.4	0.044
	B	100	5.0	0.6	<0.001
	B	1000	8.4	0.6	<0.001
	L	10	2.0	0.5	0.018
	L	100	2.7	0.4	<0.001
	L	1000	7.8	0.7	<0.001
	T	10	3.0	0.3	0.273
	T	100	4.6	2.9	0.023
	T	1000	11.2	2.3	<0.001
MMP-2	B	10	7.5	0.6	0.501
	B	100	23.1	4.5	0.002
	B	1000	92.5	14.2	<0.001
	L	10	5.5	0.6	0.100
	L	100	12.7	3.4	<0.001
	L	1000	41.2	5.2	<0.001
	T	10	3.6	0.6	0.706
	T	100	14.4	3.0	<0.001
	T	1000	30.5	6.4	<0.001
MMP-3	B	10	8.9	0.9	1.000
	B	100	14.9	3.8	0.604
	B	1000	234.0	34.7	<0.001
	L	10	4.2	0.8	1.000
	L	100	6.1	0.7	0.432
	L	1000	69.8	10.9	<0.001
	T	10	11.4	2.2	0.030
	T	100	31.6	5.8	<0.001
	T	1000	63.3	9.2	<0.001
MMP-9	B	10	2.3	0.3	1.000
	B	100	11.5	1.6	0.001
	B	1000	45.8	5.7	<0.001
	L	10	10.6	1.9	0.019
	L	100	17.0	2.5	<0.001
	L	1000	86.2	8.9	<0.001
	T	10	6.5	0.6	<0.001
	T	100	9.8	0.9	<0.001
	T	1000	12.6	2.1	<0.001
MMP-17	B	10	3.9	2.2	1.000
	B	100	63.2	13.4	0.006
	B	1000	176.5	47.9	<0.001
	L	10	2.3	1.1	1.000
	L	100	4.9	1.7	1.000
	L	1000	173.1	74.7	<0.001
	T	10	4.8	1.7	0.105
	T	100	8.8	1.7	0.002
	T	1000	18.5	4.8	<0.001
TIMP-1	B	10	67.6	8.3	<0.001
	B	100	49.8	6.7	<0.001
	B	1000	39.2	5.2	<0.001
	L	10	71.0	10.2	<0.001
	L	100	61.3	11.9	<0.001
	L	1000	31.3	6.5	<0.001
	T	10	85.9	11.5	0.038
	T	100	48.1	6.3	<0.001
	T	1000	30.0	8.7	<0.001
TIMP-2	B	10	89.2	10.8	0.082
	B	100	50.2	7.5	<0.001
	B	1000	49.6	5.3	<0.001
	L	10	66.7	11.6	<0.001
	L	100	49.7	7.1	<0.001
	L	1000	29.0	6.6	<0.001
	T	10	72.2	9.1	<0.001
	T	100	62.4	6.2	<0.001
	T	1000	30.1	4.6	<0.001

P one-way ANOVA with Bonferroni’s post hoc test for multiple comparisons

B bimatoprost, L latanoprost, T tafluprost

Dose: μM