Table 7.
Combinations of different methylation markers to create a panel of genes most suited as triage test in HPV-positive scrapings ranked on highest sensitivity (n = 152)
| Gene combination | Sensitivity CIN2+ | Specificity CIN2+ | Sensitivity CIN3+ | Specificity CIN3+ |
|---|---|---|---|---|
| JAM3/CDH6 | 80 % | 64 % | 88 % | 50 % |
| ANKRD18CP/CDH6/EPB41L3 | 79 % | 61 % | 89 % | 51 % |
| CDH6/EPB41L3 | 77 % | 61 % | 88 % | 53 % |
| GFRA1/EPB41L3/CDH6 | 78 % | 61 % | 88 % | 53 % |
| ANKRD18CP/CDH6 | 77 % | 61 % | 85 % | 51 % |
| GFRA1/ANKRD18CP/CDH6 | 77 % | 61 % | 85 % | 51 % |
| JAM3/EPB41L3/ANKRD18CP | 78 % | 72 % | 88 % | 58 % |
| C13ORF18/JAM3/ANKRD18CP a | 77 % | 81 % | 85 % | 61 % |
| ANKRD18CP/EPB41L3 | 75 % | 75 % | 86 % | 63 % |
| GFRA1/EPB41L3/ANKRD18CP | 75 % | 75 % | 86 % | 63 % |
| C13ORF18/CDH6 | 73 % | 61 % | 83 % | 54 % |
| JAM3/GFRA1/ANKRD18CP a | 76 % | 81 % | 85 % | 63 % |
| C13ORF18/JAM3/EPB41L3 | 76 % | 72 % | 86 % | 60 % |
| GFRA1/CDH6 | 72 % | 64 % | 83 % | 57 % |
| JAM3/ANKRD18CP a | 76 % | 83 % | 85 % | 64 % |
| JAM3/EPB41L3 | 75 % | 75 % | 86 % | 63 % |
| JAM3/EPB41L3/GFRA1 | 75 % | 75 % | 86 % | 63 % |
| GFRA1/EPB41L3 | 72 % | 78 % | 85 % | 68 % |
| C13ORF18/EPB41L3 | 72 % | 75 % | 85 % | 65 % |
| C13ORF18/JAM3/GFRA1 | 70 % | 86 % | 81 % | 71 % |
| JAM3/GFRA1 | 69 % | 89 % | 81 % | 74 % |
| C13ORF18/ANKRD18CP | 68 % | 83 % | 76 % | 67 % |
| C13ORF18/JAM3 | 69 % | 92 % | 80 % | 74 % |
| GFRA1/ANKRD18CP | 67 % | 83 % | 76 % | 68 % |
aThese gene combinations showed the highest combined sensitivity and specificity