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. 2016 Mar 8;9:20. doi: 10.1186/s13045-016-0253-6

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© You et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Metformin together with sorafenib suppressed recurrence and metastasis of HCC after surgical resection. a Recurrent tumor in different treatment groups. b The size (mm³) of tumors was determined. c Metastatic tumor nodules were detected by HE staining in lung(100×). d Average number of metastatic tumor nodules in lung. Error bars represent the standard deviation (*P < 0.05, **P < 0.01)