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. 2016 Mar 9;16:95. doi: 10.1186/s12906-016-1076-2

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© Yang et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Begg’s funnel plot of integrity of BBB. There was evidence of small study effects (Egger’s test bias coefficient = −8.2850, 95 % CI: −10.3545 to −6.21546, P <0.001)