Table 3.
Characteristics of included studies
| Study | Animal Species | Treatment Groups(Drug/Dose) | Anaesthetic used | Time of administration | Main Outcomes | Quality Score |
|---|---|---|---|---|---|---|
| Long 2001 [1] | Mixed Kunming mice | ①Naozhenning Granule(13.33 g/kg) ②Naochuangning (9.08 g/kg) ③Naochuangning (18.16 g/kg) ④Naochuangning (36.33 g/kg) |
Unknown | 7 days before injury Daily for 10 days |
Cerebral edema BBB permeability |
2 |
| Zhang 2002 [3] | SD rats | ①Brain injury compound decoction (unknown) | Ether | 3 days before injury Daily for 10 days |
Independent activity Cognitive performance |
4 |
| Wang 2003 [4] | Mixed Wistar rats |
①Naozhenning Granule(13.13 g/kg) ②Naochuangning (9.15 g/kg) ③Naochuangning(19.10 g/kg) ④Naochuangning (38.10 g/kg) |
Pentobarbital | After injury Daily for 14 days |
Memory performance Endothelia content |
4 |
| Zhang 2004 [5] | SD rats | ①Tongfujiannao Oral Liquid(7.5 g/kg) ②Tongfujiannao Oral Liquid(3.125 g/kg) |
Unknown | After injury Daily for 3 days |
Brain water content MDA\SOD content(Brain) \LPS content(Plasma) Histopathological | 3 |
| Cui 2005a [6] | Male SD rats | ①Naoshuning(15 g/kg) | chloral hydrate |
3 days before injury Twice for 4 days |
Neurological function Histopathological Brain water conte |
3 |
| Cui 2005b [7] | Male SD rats |
①Naoshuning(15 g/kg) | chloral hydrate |
3 days before injury Twice for 4 days |
BBB permeability Brain water content MMP-9 |
3 |
| Yu 2005 [8] | Kunming mice |
①Shenqi Extraction (0.28 g/kg) ②Shenqi Extraction (0.14 g/kg) ③Shenqi Extraction (0.07 g/kg) |
Ether | 3 days before injury Daily for 3 days |
BBB permeability Brain water content TNF-α(Brain)\ ET content(Serum) |
4 |
| Zhou 2007 [9] | Mixed SD rats |
① Huayu capsule (1.030 g/kg) ② Huayu capsule (0.515 g/kg) ③ Huayu capsule (0.258 g/kg) |
chloral hydrate |
After injury Daily for 7 days |
① Nerve-muscle catching capability. ② Histopathological |
3 |
| Cui 2008a [10] | Male SD rats |
①Naoshuning(7.5 g/kg) | chloral hydrate |
3 days before injury Twice for 4 days |
Brain water content BBB permeability AQP-4 content |
3 |
| Cui 2008b [11] | Male SD rats |
①Naoshuning(7.5 g/kg) | Unknown | 3 days before injury Twice for 4 days |
BBB permeability Histopathological cerebral microvascular density |
3 |
| Miao 2008 [12] | Male Wistar rats |
①Brain Compound decoction(10 g/kg) | Pentobarbital | Immediately after injury Twice for 7 days |
Na+-K+-ATP Ca2+-ATP |
5 |
| Cui 2009a [13] | SD rats | ①Naoshuning(7.5 g/kg) | Unknown | 3 days before injury Daily for 3 days |
Histopathological (HE statin) Edema volume Brain water content |
3 |
| Cui 2009b [14] | Male SD rats |
①Naoshuning(7.5 g/kg) | Unknown | 3 days before injury Twice for 8 days |
MMP-2/9 content Brain water content EB content |
3 |
| Xiong 2009 [15] | SD rats | ①Quyu Tongfu decoction(10 ml/kg) ②compound Huangjinxiang extraction liquid(10 ml/kg) |
Pentobarbital | 20 min after injury Daily for 24 h |
AQP- 4 content | 5 |
| Xie 2010 [16] | Mixed SD rats |
① Angong Niuhuang Pill(0.6 g/kg) | chloral hydrate |
12 h before injury Twice for 60 h |
Synaptic density BBB permeability Cerebral edema |
3 |
| Xu 2010 [17] | Mixed SD rats |
①Angong Niuhuang Pill (0.121 g/2 ml) |
Pentobarbital | After injury Daily for 12 days |
ApoE content (Brain and CSF) | 4 |
| Miao 2011 [18] | Male Wistar rats |
①Brain Compound decoction(10 g/kg) | Pentobarbital | Immediately after injury Twice for 7 days |
NO\nNOS(Brain) Brain water content Histopathological |
5 |
| Zhang 2011 [19] | Wistar rats | ①Sanhuang Xiexin Decoction(10 g/kg) | chloral hydrate |
Immediately after injury Daily for 72 h |
NF-κB\IL- 6 content | 3 |
| Wang 2012a [20] | SD rats | ①Longxuejie capsule (2.6 mg/g/d) | Unknown | after injury Daily for 5d |
NO\TNF-α content (serum) | 3 |
| Wang 2012b [21] | Male SD rats |
①modified “Shengyu”decoction 4.0 mL/200 g/d | Unknown | 6 h after injury Twice for 72 h |
Histopathological caspase-3 activity | 3 |
| Zhao 2012 [22] | Mixed SD rats |
①JiannaoYizhi capsules(6.0 g/kg/d) | chloral hydrate | 24 h after injury Daily for 10d |
CGRP content (Plasma) | 3 |
| Zhou 2012 [23] | SD rats | ①JiannaoYizhi capsules(6.0 g/kg/d) | chloral hydrate | 24 h after injury Daily for 10d |
NPY content (serum) | 3 |
| Fan 2013a [24] | SD rats | ①JiannaoYizhi capsules(6.0 g/kg/d) | chloral hydrate | 24 h after injury Daily for 10d |
S100B content (serum) | 3 |
| Fan 2013b [25] | SD rats | ①JiannaoYizhi capsules(6.0 g/kg/d) | chloral hydrate | 24 h after injury Daily for 10d |
NSE content (serum) | 3 |
| Zhao 2014 [26] | Male SD rats |
①modified “Shengyu”decoction 0.5 mL/200 g ②modified “Shengyu”decoction 1.0 mL/200 g ③modified “Shengyu”decoction 2.0 mL/200 g |
chloral hydrate | 6 h after injury Daily for 7d |
Neurological function Brain water content Histopathological Lesion volume TNF-α\ IL-1\IL-6\IL-10 content (brain) |
6 |
Note: BBB Blood–brain-barrier, MMP-9 matrix metalloprotein 9, TNF-α tumor necrosis factor-α, IL-1 interleukin-1, IL-6 interleukin-6, IL-10 interleukin-10, NSE 2-phospho-D-glycerate hydrolase, NPY Neuropeptide Y, CGRP Calcitonin Gene Related Peptide, SOD superoxidedismutase, MDA malondialdehyde, NO Nitrogen monoxide, SD Sprague Dawley.-