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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Cell Signal. 2013 Mar 14;25(6):1339–1347. doi: 10.1016/j.cellsig.2013.02.022

Fig. 1.

Fig. 1

Inhibition of p38 shuts down LPS-induced cytokine production while inhibition of the Erk pathway only moderately decreases it. WT BMMCs were pretreated for 20 min with either DMSO, 1 μM PD0325901 or 0.1 μM BIRB0796, then left untreated (con) or stimulated with 3 μg/ml LPS for 4 h. Subsequently, the amounts of TNF-α (upper panel) and IL-6 (lower panel) were determined by ELISA. Each bar represents the mean of triplicates ± SD. Comparable results were obtained in several experiments using different BMMC cultures (n ≥ 3).