Table 2.
Evolution of liver biochemistries in the Month 12 persisters vs resolvers over time
| Liver biochemistries | Month 12 Persister |
Month 12 Resolver |
p-value |
|---|---|---|---|
| At DILI Onset (n) | (74) | (25) | |
| Serum AST (U/L) | 266 (29, 2125) | 367 (45, 2077) | 0.07 |
| Serum ALT (U/L) | 275 (14, 2733) | 553 (121, 2412) | 0.01 |
| Alk P (U/L) | 394 (41, 1730) | 219 (74, 783) | <.01 |
| Total bilirubin (mg/dl) | 5.2 (0.2, 29.7) | 7.2 (0.2, 36.2) | 0.24 |
| T bilirubin > 2.5 mg/dl (%) | 71% | 79% | 0.6 |
| At Month 6 (n) | (70) | (24) | |
| Serum AST (U/L) | 73 (27, 1258) | 47 (18, 140) | <.01 |
| Serum ALT (U/L) | 78 (13, 1627) | 66 (13, 216) | 0.09 |
| Alk P (U/L) | 275 (53, 1487) | 116 (32, 277) | <.01 |
| Total bilirubin (mg/dl) | 0.9 (0.1, 16.3) | 0.6 (0.4, 2.4) | 0.01 |
| T Bilirubin > 2.5 mg/dl (%) | 13% | 0% | 0.11 |
| At Month 12 (n) | (74) | (25) | |
| Serum AST (U/L) | 67 (29, 2335) | 29 (15, 50) | <.01 |
| Serum ALT (U/L) | 79 (16, 1223) | 40 (13, 73) | <.01 |
| Alk P (U/L) | 245 (58, 1333) | 92 (35, 151) | <.01 |
| Total bilirubin (mg/dl) | 0.9 (0.3, 33.4) | 0.6 (0.1, 2.4) | 0.03 |
| T bilirubin > 2.5 mg/dl (%) | 7% | 0% | 0.33 |
| At Month 24 (n) | (66) | (19)* | |
| Serum AST (U/L) | 50 (17, 410) | 30 (16, 558) | <.01 |
| Serum ALT (U/L) | 50 (19, 407) | 32 (9, 1211) | <.01 |
| Alk phos | 157 (54, 1389) | 82 (47, 228) | <.01 |
| Total bilirubin (mg/dl) | 0.8 (0.3, 3.8) | 0.6 (0.2, 3.7) | 0.28 |
| T Bilirubin > 2.5 mg/dl (%) | 3% | 5% | 0.54 |
Data reported as median (range)
*
A single patient with normal liver biochemistries at 12 months after DILI onset subsequently developed acute cholestatic liver injury at month 24 attributed to symptomatic gallstones.