Table 3.
Histological and clinical features of DILI patients with follow-up liver biopsies
| Age/ sex |
Primary Implicated (days of therapy) |
R value at DILI onset |
Time between biopsies (days) |
*Stage at 1st |
Stage at 2nd |
R value closest to 2nd biopsy |
Histological Diagnosis on f/u biopsy |
Duct Loss/Ductular Reaction on F/U |
|---|---|---|---|---|---|---|---|---|
| 53 F | Trimethoprim-sulfamethoxasole | 1.9 | 490 | 0 | 0 | 1.0 | Chronic. Cholestasis | No/No |
| 38 F | Celecoxib | 8.4 | 382 | 0 | 0 | 0.7 | Chronic Cholestasis | No/No |
| 20 F | Azithromycin | 7.3 | 283 | 0 | 2 | 4.5 | Chronic Cholestasis. | Yes/No |
| 45 M | Azithromycin | 62.6 | 392 | 1 | 1 | 18.6 | Chronic Hepatitis | No/No |
| 58 F | Ultravist vitamin preparation | 0.42 | 246 | 4 | 6 | 27.3 | Steatohepatitis + Cholestasis | No/Yes |
| 37 F | Tamoxifen | 17.0 | 675 | 3 | 0 | 1.3 | Steatohepatitis | No/No |
| 20 F | Olanzapine | 1.6 | 633 | 0 | 4 | 1.8 | Chronic Cholestasis | Yes/Yes |
| 52 M | Metoclopramide | 1.8 | 404 | 1 | 2 | 0.7 | Chronic Cholestasis | Yes/Yes |
| 54 F | Omeprazole | 2.5 | 331 | 0 | 2 | 1.0 | Chronic Cholestasis. | Yes/No |
| 64 M | Amoxicillin-clavulanate | 6.8 | 183 | 0 | 2 | 0.8 | Chronic Cholestasis | No/Yes |
| 56 M | Gluco-Ease Plus | 1.1 | 522 | 0 | 2 | 0.2 | Chronic Cholestasis. | Yes/No |
| 70 F | Lansoprazole | 2.4 | 217 | 0 | 1 | 3.7 | Acute Cholestasis | Yes/No |
*
Ishak fibrosis score with scale of 0 (none) to 5/6 (cirrhosis)