Table 1.

The parameters used to demonstrate the model for HNSCC.

Parameters	Values
Tumour parameters
Tumour cell density (ρt)	106 mm−3 (Zips 2009)
Volume of a tumourlet (vt)	64 mm3 (typical PET voxel size)
Total number of cells in a tumourlet (nt)	6.4 × 107 (ρt · vt)
Stem cell fraction (fs)	0.01 (Hemmings 2010)
Cell cycle time (TC)	2 days (Malaise et al 1973)
Compartment parameters
Initial proliferation fraction in P ($f_{\text{pro}}^P$)	0.5a
Cell loss half-time in H (T1/2, loss)	2 days (Ljungkvist et al 2005)
Survival rate of progeny after mitosis (km)	0.3a
Lysis half-time (T1/2, lysis)	3 daysa
Radiosensitivity parameters
Linear radiosensitivity coefficient (αP)	0.382 Gy−1 (Pekkola-Heino et al 1995)
Quadratic radiosensitivity coefficient (βP)	0.0576 Gy−2 (Chapman 2003)
OER of the I-compartment (OERI)	2.0a
OER of the H-compartment (OERH)	1.37 (Chan et al 2008)
System parameters
Time step of the calculation (Δt)	15 min

^aAssumed parameters.