Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Dynamic DNA modifications in mammals mediated by TET and TDG. DNMTs can introduce a methyl group onto the C-5 position of the cytosine base. The 5mC modification can be oxidized to 5hmC/5fC/5caC in a stepwise manner by TET proteins. 5fC and 5caC can be readily excised by TDG to generate an abasic site, which can be repaired back to unmodified cytosine through the BER pathway.
