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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Chem Rev. 2015 Feb 12;115(6):2225–2239. doi: 10.1021/cr500470n

Figure 3.

Figure 3

Overall domain architecture of TET proteins and the published human TET2 structure. (A) TET proteins contain a CXXC DNA-binding domain and a conserved catalytic domain composed of a Cys-rich region and a DSBH fold. (B) Crystal structure of the TET2–DNA complex. The Cys-rich regions bind zinc cations and are folded together with the catalytic domain. (C) Close-up view of the active site of TET2. DNA is colored orange; 5mC, NOG, and critical residues are shown in stick representations, iron is shown in a blue sphere, and zinc is shown in a gray sphere. (D) Ribbon representations of three zinc cations in TET2. Zinc cations are shown and labeled in red spheres; corresponding coordination residues are shown in stick representations.