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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Chem Rev. 2015 Feb 12;115(6):2225–2239. doi: 10.1021/cr500470n

Figure 4.

Figure 4

Proposed mechanism of TET-mediated oxidation of 5mC and its derivatives. The oxidation substrates can be 5mC, 5hmC, or 5fC. The coordination residues of iron(II) and α-KG are drawn based on the human TET2 structure.[san]98 A radical rebound mechanism is shown, but the C–H activation could also go through a more concerted process.