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. Author manuscript; available in PMC: 2016 Mar 9.
Published in final edited form as: Chem Rev. 2015 Feb 12;115(6):2225–2239. doi: 10.1021/cr500470n

Figure 6.

Figure 6

TET interacting proteins. (A) Calpains can regulate the half-life of TET enzymes. Calpain1 may regulate the degradation of TET1 and TET2, and calpain2 may regulate TET3. (B) IDAX can affect TET2 expression via caspase activation and the degradation of TET2. IDAX is separated from the catalytic domain of TET in a chromosomal gene inversion of an ancestral TET2 gene during evolution. IDAX CXXC domain binds unmethylated CpG dinucleotides and recruits TET2 to DNA. (C) TET enzymes recruit OGT to the chromatin and promote O-GlcNAcylation of histone 2B at Ser112, increasing the transcription of the corresponding genes. TET2/3 can also promote the O-GlcNAcylation activity of OCT on the host cell factor 1 (HCF1), stabilizing the integrity of H3K4 methyltransferase Set1/COMPASS.