Table 1.
Examples of drugs/agents capable of affecting some of the MDR genes in human cancer cells
| Signal chain | Blocking agents | Clinical status | Ref. |
|---|---|---|---|
| Wnt | siRNA Curcumin/Piperin Several other natural products Resveratrol |
35 clinical trials | [219–224] |
| NOTCH | siRNA Monoclonal antibodies Peptides Decoys Secretase inhibitors Several natural compounds |
15 clinical trials | [56] [54, 225] [225] [226] [53] [227] |
| Hgh | Cyclopamine (alkaloid from plants) Vismodelib Cyclosporin Sulforaphane (Broccoli) |
Several clinical trials Clinical trials |
[58, 228] [229] [58] [230] |
| NANOG | siRNA Resveratrol |
Preclinical | [231] [232] |